Iris Yuwen Zhou1,2, Kevin C. Chan1,2, Abby Y. Ding1,2, Edward S. Hui1,2, Ke Xia Cai1,2, Ed X. Wu1,2
1Laboratory of Biomedical and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China
In this study, in vivo MEMRI was employed to investigate the hypoxic-ischemic injury in the late phase. Mn2+ induced signal changes were examined using SPM coregistration and ROI analysis. T1WIs SI increase was detected in the perilesional region 24 hours after Mn2+ administration and it colocalized with the increase in glial cell density in GFAP staining, demonstrating the existence of reactive gliosis in the late phase after H-I injury.