Frederik Bernd Laun1, Bram Stieltjes1
1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Baden-Wrttemberg, Germany
We show, that in the slow diffusion limit, the classical Stejskal-Tanner gradient scheme is optimal to measure the surface-to-volume ratio using the time dependent diffusion constant approach. We further show data supporting the assumption that S/V can not be determined properly by just shaping the gradients, e.g. using a train of short gradients, if the slow diffusion condition is not fulfilled as has been proposed previously.