Johanna Nrvinen1, Kimmo T. Jokivarsi2, Penny Louise Hubbard3, Olli H. Grohn4, Risto A. Kauppinen5, Gareth A. Morris6
1Biomedical Imaging Unit, University of Kuopio, Kuopio, Finland; 2Dept. of Neurobiology, University of Kuopio, Kuopio, Finland; 3School of Medicine, University of Manchester, Manchester, UK; 4Dept. of Neurobiology, University of Kuopio, Kuopio, Finland; 5Dept. of Radiology, Dartmouth College, Hanover, NH, USA; 6School of Chemistry, University of Manchester, Manchester, UK
T2-selective Z-spectroscopy (ZAPI) was applied to acute cerebral ischemia. It was shown that the magnetization transfer (MT) component can be measured directly at and near water resonance using sinusoidally modulated low-power RF saturation. This information was used to improve the separation of MT from other components in a Z-spectrum. In this study, a small decrease in MT asymmetry in stroke was observed. In the ischemic striatum the amide signals at 3.5 ppm showed decreased amide-water exchange, while aliphatic signals at -3.5 ppm remained unchanged.