Marie-France Penet1, Samata Kakkad1, Dmitri Artemov1, Zaver M. Bhujwalla1
1Department of Radiology and Radiological Science, JHU ICMIC Program, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cachexia occurs with a high frequency in several cancers. The significant weight loss resulting from this condition causes impairment of immune function, poor outcome of chemotherapy, fatigue, and markedly reduced quality of life. The ability to noninvasively identify cachexia-inducing tumors, and understand the metabolic characteristics of these tumors is important for determining new targets to arrest or reverse this condition. Here we report on the metabolic differences, identified by 1H magnetic resonance spectroscopy (MRS), between cachectic and non-cachectic tumors.