Christine L. MacDonald1, Nicholas Hubbard1, Sanjeev Vaishnavi1, Adrian Epstein1, Abraham Snyder1, Stephanie Chleboun2, Joshua Shimony1, Marcus Raichle1, David Brody1
1Washington University, Saint Louis, MO, USA; 2Southern Illinois University Edwardsville, Edwardsville, IL, USA
Diffuse axonal injury is hypothesized to be the primary cause of cognitive deficits following traumatic brain injury (TBI). Currently clinical imaging modalities are not optimized to assess this pathology. 20 chronic TBI patients and 12 controls were scanned with diffusion tensor imaging and resting-state fMRI at 3T. Detailed neuropsychological assessments were performed the same day. Highly significant correlations were found between several aspects of cognitive performance and imaging abnormalities detected on DTI or resting-state fMRI analysis of functional connectivity. Conventional anatomical sequences did not reveal these pathologies. Thus, these advanced MRI techniques could be synergistically used to better assess TBI.