Peder E. Z. Larson1, Simon Hu1, Michael Lustig2, Adam B. Kerr2, Sarah J. Nelson1, John Kurhanewicz1, John M. Pauly2, Daniel B. Vigneron1
1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA; 2Electrical Engineering, Stanford University, Stanford, CA, USA
We have developed and applied a compressed sensing acquisition and reconstruction scheme for repeated accelerated acquisitions for 3D dynamic time-resolved MRSI for hyperpolarized carbon-13 studies. This sequence also uses multiband RF excitation pulses to efficiently utilize the hyperpolarized magnetization. The compressed sensing exploits the spectral sparsity and temporal redundancy while the multiband pulses take advantage of the different metabolite concentrations in order to obtain dynamic serial 3D MRSI with a time resolution of 5 s over 50 seconds after injection of hyperpolarized [1-13C]-pyruvate.