Gerard Thompson1, John Robert Cain1, Samantha Jane Mills1, Alan Jackson1
1Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
Described in this work is a method for quantifying the change in apparent diffusion coefficient (ADC) which occurs across tissue boundaries in glioblastoma multiforme on diffusion-weighted imaging. The gradient of the change in ADC moving from peri-tumoural oedema into solid, enhancing tumour was found to correlate with length of survival (n=18; Kendalls tau -0.401, p0.021; Coxs Hazards Ratio 1.007 (1.001-1.014) p=0.032), whereas the ADC gradient measured from normal appearing white matter into peri-tumoural oedema did not (n=19; Kendalls τ 0.164, p0.327; Coxs Hazards Ratio 0.998 (0.998-1.008) p=0.695).