Yoshitaka Bito1, Koji Hirata1, Toshihiko Ebisu2, Yuko Kawai3, Yosuke Otake1, Satoshi Hirata1, Toru Shirai1, Yoshihisa Soutome1, Hisaaki Ochi1, Masahiro Umeda3, Toshihiro Higuchi4, Chuzo Tanaka4
1Central Research Laboratory, Hitachi, Ltd., Kokubunji-shi, Tokyo, Japan; 2Neurosurgery, Nantan General Hospital, Kyoto, Japan; 3Medical Informatics, Meiji University of Integrative Medicine, Kyoto, Japan; 4Neurosurgery, Meiji University of Integrative Medicine, Kyoto, Japan
A diffusion-weighted line-scan echo-planar spectroscopic imaging (DW-LSEPSI) technique to improve accuracy in measuring diffusion-weighted images of metabolites is developed.@The most challenging issue to improve accuracy is to reduce motion artifact induced by cardiac pulsation and respiratory. The developed technique uses line-scan technique and echo-planar technique to reduce the influence of phase errors caused by such motions during diffusion time. Acquisition of accurate diffusion-weighted image and ADC maps of metabolites is demonstrated by applying this technique to a phantom and a rat brain in vivo.