Jieun Kim1, In-Young Choi1,2, Mary L. Michaelis3, Sang-Pil Lee1,4
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA; 2Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA; 3Department of Pharmacology and Toxocology, University of Kansas, Lawrence, KS, USA; 4Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
Axonal transport deficit has been implicated as a common mechanism of Alzheimers disease (AD) pathology. We used MEMRI to measure fast axonal transport rates in olfactory bulbs and olfactory cortex of a triple transgenic mouse model of AD (3xTg). Our results indicate that axonal transport deficit starts as early as 3 months of age and precedes Aβ plaque and neuro-fibrillary tangle pathology.