Andreia Vasconcellos Faria1,2, Julia Choi1, Eileen Patti Vining1, Jiangyang Zhang1, Kenishi Oishi1, Xin Li3, Hangyi Jiang1, Kazi Akhter1, Peter van Zijl1,3, Michael I. Miller4, Amy Bastian1,3, Susumu Mori1
1Johns Hopkins Medical Institutes, Baltimore, MD, USA; 2State University of Campinas, Campinas, SP, Brazil; 3Kennedy Krieger Institute, Baltimore, MD, USA; 4Center for Imaging Studies, Johns Hopkins Medical Institutes, Baltimore, MD, USA
We investigated the remaining brain architecture of hemispherectomy patients using Diffusion Tensor Images (DTI) that provide suitable intra-white matter contrast. Using a nonlinear warping algorithm based on large deformation, diffeomorphic metric mapping (LDDMM) we registered participants into common coordinates. The recently established brain atlas was used to automatically segment the brains which enabled us to investigate differences in individual regions. This method clearly identified areas of Wallerian degeneration in white matter and detected increased FA in gray matter structures. Unexpected results included the lack of FA abnormalities in the medial lemniscii and "fiber mixing areas" in the corona radiata.