Claudia Prieto1, Sergio Uribe1, Philip Batchelor1, Pablo Irarrazaval2, Reza Razavi1, David Atkinson3, Tobias Schaeffter1
1Division of Imaging Sciences, King's College London, London, UK; 2Departamento de Ingenieria Electrica, Pontificia Universidad Catolica de Chile, Santiago, Chile; 3Centre for Medical Imaging Computing, University College of London, London, UK
Iterative SENSE reconstruction for non-Cartesian undersampling leaves residual aliasing and produces noise amplification because the ill-conditioned nature of the inverse problem. We proposed a new undersampled dynamic acquisition and reconstruction method for 3D DCE-MRI. It combines a 3D radial phase-encoding trajectory with the golden angle profile order, providing explicit regularization for iterative reconstructions. This approach takes advantage of the trajectory's properties to generate a regularization image. Moreover, since the acquisition is based on the golden angle, the regularization can be changed adaptively for each frame. The method was tested with synthetic phantoms and in-vivo showing excellent results with undersampling factors up to 49.