Nikolai Vladimirovich Malykhin1,2, Robert Marc Lebel1, Nicholas J. Coupland3, Rawle Carter3, Peter Seres1, Alan H. Wilman1
1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; 3Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Changes in the hippocampus have often been implicated to the pathophysiology of many neurological and psychiatric diseases. Current MRI studies measure global hippocampal atrophy instead of measuring volume loss in its subfields. The purpose of this study was to delineate and quantify the hippocampal subfields in-vivo within entire hippocampal structure using ultra-high resolution Fast Spin Echo (FSE) imaging at 4.7T.