Osamu Sakai1, Steven Kussman1, Al Ozonoff2, Koji Tanabe1, Kaan Erbay1, Memi Watanabe1, Naoko Saito1, Hernan Jara1
1Radiology, Boston University School of
Medicine, Boston, MA, USA; 2Biostatistics, Boston University School
of Public Health, Boston, MA, USA
Purpose: To study the age dependencies of apparent diffusion coefficient (ADC) histogram of the brain in the large and wide age ranged population. Also to develop peak and width ADC vs. age mathematical model valid over the full human lifespan. Methods: Brain data of 767 subjects (15 days-93.8 years) obtained by SS-DW-SE-EPI were segmented into the whole intracranial matter leading to ADC histograms. Results: ADC peak value, as well as histogram width of the whole brain showed clear age-related patterns. Conclusion: The mathematical models for ADC peak value and histogram width vs. age valid throughout life have been developed with 767 subjects.