Sarah Andrea Wijtenburg1,2, Kathleen L. Fuchs3, Virginia I. Simnad3, Jack Knight-Scott1,2
1Radiology, Children's Healthcare of Atlanta, Atlanta, GA, USA; 2Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; 3Neurology, University of Virginia, Charlottesville, VA, USA
Here, we employ short TE 1H MRS to investigate changes to cerebral metabolite concentrations in the posterior cingulate gyrus as a function of age and gender: healthy young (HY), healthy middle-aged (HM), and healthy elderly (HE). Choline (p=0.003, 87% power) was the only metabolite that exhibited any significant differences: HE and HM as well as HE and HY, and this effect was driven by changes in men.