Masami Goto1, Osamu Abe2, Sachiko Inano2, Tosiaki Miyati3, Naoto Hayashi4, Shigeki Aoki5, Harushi Mori2, Hiroyuki Kabasawa6, Kenji Ino1, Keiichi Yano1, Kyouhito Iida1, Kazuo Mima1, Kuni Ohtomo2
1Radiological Technology, University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan; 2Radiology, University of Tokyo, Bunkyo-ku, Tokyo, Japan; 3Graduate School of Medical Science, Kanazawa University, odateno, Kanazawa, Japan; 4Computational Diagnostic Radiology and Preventive Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan; 5Radiology, Juntendo University, Bunkyo-ku, Tokyo, Japan; 6Japan Applied Science Laboratory , GE Yokogawa Medical Systems, Ltd , Hino-shi, Tokyo, Japan
Lord et al. studied the relation between estrogen therapy and hippocampal volume in estrogen therapy users, past users, never users, and men, and suggested a positive association between estrogen and hippocampal volume [1]. In the present study, a significant decrease in gray matter volume was found in the hippocampus bilaterally in the postmenopausal group compared with the premenopausal group. The results of the current study suggest that the decreased release of estrogen in menopausal women may be associated with hippocampal volume reduction.