Toshiaki Taoka1, Toshiaki Akashi1, Toshiteru Miyasaka1, Hiroyuki Nakagawa1, Kaoru Myochin1, Satoru Iwasaki2, Kimihiko Kichikawa1
1Radiology, Nara Medical University, Kashihara, Nara, Japan; 2Radiology, Higashiosaka City General Hospital, Japan
The purpose of this study is to evaluate changes in fibers of limbic circuit using tract-based diffusion tensor analysis as an indicator of severity of Alzheimer disease (AD) and mild cognitive impairment (MCI). Increased diffusivity and decreased diffusion anisotropy in limbic circuits correlated to the severity of AD and MCI. Degeneration of white matter fiber tracts secondary to neuronal loss in the associative cortex may be one of the reasons of these AD associated changes in limbic circuits. Decreased FA and increased ADC may be useful as a marker for severity of AD.