Takashi Yoshiura1, Akio Hiwatashi1, Koji Yamashita1, Eiki Nagao1, Hironori Kamano1, Yukihisa Takayama1, Osamu Togao1, Tuvshinjargal Dashjamts1, Tomoyuki Noguchi1, Ivan Zimine1, Tomoyuki Okuaki2, Hiroshi Honda1
1Department of Clinical Radiology, Kyushu University, Fukuoka, Japan; 2Philips Electronics Japan, Tokyo, Japan
We compared diagnostic performances of ASL CBF measurement, morphometric measurement and combined two methods in detecting Alzheimerfs disease (AD). Twenty AD patients and 23 healthy control subjects were studied using quantitative ASL and high-resolution structural imaging. Discrimination of AD patients from control subjects was performed based on mean CBF in the hypoperfused area and gray matter density in the atrophied region. Diagnostic accuracy for ASL CBF, gray matter density and their combination were 86.0%, 88.4% and 93.0 %, respectively. Results suggest combination of ASL CBF measurement and morphometric imaging can provide better diagnostic accuracy than either of the two alone.