Kuniaki Kiuchi1, Masayuki Morikawa1, Toshiaki Taoka2, Soichiro Kitamura3, Tomohisa Nagashima1, Kazumichi Hashimoto1, Jun Kosaka1, Yuichiro Inoue1, Makoto Inoue1, Kimihiko Kichikawa2, Toshifumi Kishimoto1
1Psychiatry, Nara Medical University, Kashihara, Nara, Japan; 2Radiology, Nara Medical University, Kashihara, Nara, Japan; 3Neuropsychiatry, Tenri Hospital, Tenri, Nara, Japan
Introduction: We investigate white matter using diffusion tensor tractography between subjects with Alzheimerfs disease (AD) and dementia with lewy bodies (DLB). Method: 15 AD, 15 DLB, and 16 controls underwent diffusion tensor tractography. We measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the nerve bundles in white matter. Result: In the posterior cingulum bundle (PCB) and uncinate fasciculus (UNC), significant differences were observed between AD and controls. DLB exhibited significantly lower FA and higher ADC values in the PCB relative to NC. Conclusion: Subjects with AD and DLB exhibit white matter abnormality relative to controls.