Hong Yang1, Yi-Lei Zhao1, Jun-Feng Xu1, Xu-Ning Zheng2, Dong-qiang Liu3, Min-ming Zhang1
1Department of Radiology , First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, China; 2Department of Neurology, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, China; 3State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University. Beijing, Chi, Beijing, China
The purpose of this study is to investigate the changes of volume and concentration in cerebral grey matter in patients with early Parkinsons disease (PD) using an optimized voxel-based morphometry (VBM) protocol. Twenty-one patients were compared with an equivalent number of age- and gender- matched controls. 3D T1-weighted images of the whole brain were acquired, followed by data processing using SPM5 software. The PD patient group exhibited increased grey matter concentration in right middle frontal gyrus and increased grey matter volume in the left middle frontal area and the right cuneous area, a finding that has not been reported in the literature.