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Abstract #1120

Dynamic Contrast Enhanced (DCE) Perfusion Indices as a Measure of Blood Brain Barrier (BBB) Disruption in Different Stages of Neurocysticercosis

Rishi Awasthi1, Avantika Verma2, Vimal Kumar Paliwal3, Sanjay Kumar Verma4, Kashi Nath Prasad2, Ram Kishore Singh Rathore4, Rakesh K. Gupta1

1Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 3Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 4Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh


DCE MRI was performed on 15 patients with Neurocysticercosis (NCC), cysts at different stages of degeneration. Various perfusion indices were analyzed and it was found that Ktrans, Kep, ve and vp were significantly high and showed positive correlation with degree of oedema in cysts with edema compared to other groups. We conclude that perfusion indices may be used to quantify degree of BBB disruption, which may be of value in understanding the mechanism of disease symptoms in future.