ystein Olsen1, Pl Erik Goa2, Andres Kristoffersen3, Axel Sandvig4, Christian Brekken2, Marte Thuen5
1Department of Radiography, Sr-Trndelag University College, Trondheim, Norway; 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology,, Trondheim, Norway; 3Department of Radiology,, St Olavs Hospital, Trondheim, Norway; 4Department of Laboratory Medicine Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; 5Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
A mono-exponential decaying concentration function and a constant concentration function were used as input function to a mathematical model for transport of manganese in the optic nerve. With the mono-exponential decaying function, it was not possible to fit the model to the measured time intensity curve, however, by using the constant concentration input function we were able to fit the model quite nicely with the measured data. The study indicate that the influx of manganese into the retinal ganglion cells through voltage gated calcium channels is limited by the uptake rate through these channels rather than the manganese concentration in the vitreous body.