Yoji Tanaka1, Tsukasa Nagaoka1, Govind Nair1, Qiang Shen1,2, Xiaodong Zhang1, Timothy Q. Duong1,2
1Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA, USA; 2Research
Imaging Center, University of Texas Health Science Center at San Antonio, San
Antonio, TX, USA
In the treatment of acute phase ischemic stroke, tPA has high risk of hemorrhage which is usually fatal, and the treatment time window is very narrow. The aim of this study is to examine a novel combination therapy of recombinant annexin 2 and low dose rtPA for acute ischemic stroke with employing MRI. We conclude that the combination therapy has a possibility to reduce the harmful side effect of rtPA without reducing its benefits as treatment.