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Abstract #1397

Axon Radius Estimation Using Optimised StejskalTanner and Dual Spin-Echo Sequences at Modest SNR

Jonathan D. Clayden1, Zoltan Nagy2, Daniel C. Alexander3, Chris A. Clark1

1Institute of Child Health, University College London, London, England, UK; 2Wellcome Trust Centre for Neuroimaging, University College London, London, England, UK; 3Department of Computer Science, University College London, London, England, UK


This work describes a process for optimising both Stejskal-Tanner and dual spin-echo diffusion weighted EPI sequences, for the specific purpose of estimating axon radius or other microstructural properties of white matter. The dual spin-echo sequence is optimised with and without eddy-current nulling. We compare the sequences' suitabilities for estimating axon radius, and demonstrate their ability to recover radius information, even with modest gradient strength and SNR.