1Biomedical Engineering, Loma Linda University, Loma Linda, CA, USA; 2Non-invasive Imaging Lab, Radiation Medicine, Loma Linda University, Loma Linda, CA, USA
Diffusion anisotropy has been widely used to identify white matter, but is sensitive to noise and the disease processes. The major eigenvector of diffusion tensor, V1, has been widely used to reconstruct neural tractography. We converted V1 to an objective DTI index, the intra-voxel V1-IP, to serve as an objective DTI index to differentiate white matter from gray matter and ventricles. Comparing the intra-voxel V1-IP and relative anisotropy (RA), we demonstrated that intra-voxel V1-IP is a better white matter index than RA as it is insensitive to noise and neuronal diseases.