Chien-Chung Chen1, Young Ro Kim2, Yi-Chun Wu1, Chou-Ming Cheng3, Tzu-Chen Yeh3, Fu-Nien Wang1
1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, Taiwan; 2Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; 3Integrated Brain Research Laboratory, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan
A hybrid method combing the advantage of Vascular Space Occupancy, Dynamic Susceptibility Contrast imaging, and susceptibility induced R2 increase by long half-life contrast agent MION are proposed to measuring absolute cerebral blood volume (CBV) with multiple slices on animal model. The correlation between these method are high and therefore a regression can be utilized to convert multi-slices relative CBV values to absolute quantifications, which could be beneficial to measuring whole brain perfusion on animal experiments.