Xiufeng Li1, Subhendra Sarkar2, Robert W. Haley3, Richard W. Briggs3,4
1Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, USA; 2Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; 4Radiolody, UT Southwestern Medical Center, Dallas, TX, USA
When FAIR with Q2TIPS is applied for perfusion studies of specific brain regions, such as cerebellum, the superior labeled venous blood generates huge undesired artifacts, making CBF estimation in neighboring tissue unreliable. To avoid these adverse artifacts in cerebellum perfusion studies, a modulated dual saturation pulse trains for FAIR (MDS FAIR) technique was implemented and evaluated by performing perfusion studies in the cerebellum. The study results show that the MDS FAIR can greatly minimize these adverse venous artifacts. This technique should also be valuable for perfusion studies of other organs and tissues where similar problems exist.