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Abstract #1538

Comparing Kidney Perfusion Using Arterial Spin Labeling and Microsphere Methods in an Interventional Swine Model

Nathan Artz1, Andrew Wentland1, Elizabeth Sadowski2, Zhifei Wen1, Thomas Grist1,2, Arjang Djamali3, Sean Fain1,2

1Medical Physics, University of Wisconsin, Madison, WI, USA; 2Radiology, University of Wisconsin, Madison, WI, USA; 3Nephrology, University of Wisconsin, Madison, WI, USA


Two methods of measuring cortical kidney perfusion, fluorescent microspheres and ASL-FAIR, are compared for 5 swine at four time points: under baseline conditions, during an acetylcholine and fluid bolus challenge, and at baseline and after 2 hours of isoflurane anesthesia with ice placed on one of the kidneys. ASL correlates well with microspheres at every time point during the experiment, with a rho = 0.7.