kirsten Gilday1, chris McCabe2, William Matthew Holmes2, Mhairi Macrae2, anna Dominiczak1
1BHF Glasgow Cardiovacular Research Centre, University of Glasgow, UK; 2Clinical Neuroscience, University of Glasgow, Glasgow, Scotland, UK
The stroke-prone spontaneously hypertensive rat (SHRSP) is an excellent experimental model of essential hypertension. In addition, this strain demonstrates left ventricular hypertrophy. In humans, echocardiography and MRI are used as quick, non-invasive and accurate procedures for measuring cardiac parameters.The aim was to demonstrate the validity of echocardiography and self gated cardiac MRI as high fidelity, high throughput techniques for characterising cardiac differences in mass and function in 16 week old SHRSP, normotensive Wistar Kyoto (WKY) rats and the congenic strain SP.WKYGla14a.