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Abstract #2059

Intra-Voxel Incoherent Motion MRI in Rodent Model of Diethylnitrosamine-Induced Liver Fibrosis

Yue Zhang1,2, Ning Jin2,3, Jie Deng2, Tamuna Chadashvili2, Yang Guo2, Guang-yu Yang4, Andrew Christian Larson2,5

1Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA; 2Department of Radiology, Northwestern University, Chicago, IL, USA; 3Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA; 4Department of Pathology, Northwestern University, Chicago, IL, USA; 5Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA


Intra-voxel incoherent motion (IVIM) imaging permits in vivo quantification of diffusion and perfusion. The purpose of our study was to investigate the relationship between hepatic IVIM measurements and diethylnitrosamine-induced fibrosis levels in the Wistar rat model.