Gavin Hamilton1, Michael S. Middleton1, Takeshi Yokoo1, Joel E. Lavine2, Heather M. Patton3, Claude B. Sirlin1
1Department of Radiology, University of California, San Diego, San Diego, CA, USA; 2Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of San Diego, San Diego, CA, USA; 3Department of Medicine, University Of California, San Diego, San Diego, CA, USA
In liver 1H MR spectroscopy, spectra are often collected at a single TE, and thus the lack of T2 correction may introduce possible confounding factors. This study collects 3T MR Spectra at multiple TEs and shows correction for T2 decay is necessary for liver fat quantification to avoid systematic over-estimate of fat fraction. Collecting multiple TE spectra also minimizes errors due to T2 variability.