Khushali Kotedia1, Jadegoud Yaligar1, Kaitlyn Kelly2, Joyce Wong2, Jason A. Koutcher1, Yuman Fong2, Kristen L. Zakian1
1Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA; 2Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA
Levels of 31P metabolites in the mouse liver following partial hepatectomy (70% PH) were quantitated by 31P magnetic resonance spectroscopic imaging (MRSI) to determine whether 31P metabolites were non-invasive markers of regenerative status. In each of the 2 phases of this study, the mean NTP level decreased after PH but did not differ significantly from controls. Significant changes in PME and/or PE and PC were not observed. SNR limitations due to the very small liver remnant volume as well as inter-subject heterogeneity may have resulted in statistical uncertainty that obscured the detection of metabolic changes.