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Abstract #2182

Abnormal Ventilation Assessed with Hyperpolarized 3He MRI in Young Cystic Fibrosis Patients with Normal Lung Function. Evaluation of Immediate Influence of a Single Chest Physiotherapy Session.

Elise Bannier1, Katarzyna Cieslar1, Karim Mosbah1, Francoise Aubert2, Francois Duboeuf1, Zahir Salhi3, Sophie Gaillard1, Yves Berthezne1, Philippe Reix4, Yannick Crmillieux1

1Universit de Lyon, CREATIS LRMN, Lyon, France; 2Centre d'Investigation Clinique, Lyon, France; 3Johannes Gutenberg Universitt, Mainz, Germany; 4Service de Pdiatrie, Hpital Femme Mre Enfant, Lyon, France

The aim of the study was to assess the ability of 3He MRI to detect lung ventilation abnormalities in pediatric patients with normal pulmonary function tests (PFT) and to observe the immediate effect of a single chest physiotherapy session (CPT). Ventilation defects were observed and quantified pre and post CPT.