Kiarash Emami1, Jiangsheng Yu1, Stephen Kadlecek1, John MacDuffie-Woodburn1, Jianliang Zhu2, Stephen Pickup1, Matthew Stetz1, Masaru Ishii3, Michael Stephen4, Rahim Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, PA, USA; 3Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA; 4Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
The accuracy of measurements of regional lung ventilation using a sequential series of hyperpolarized 3He breaths highly depends on the applied RF pulse flip angle. Assessment of optimum flip angle subject to a satisfying performance index in presence of model parameter uncertainty is the subject of this study.