Nagarajan Rajakumar1, Ana Maria Gomez1, Daniel Margolis1, Steven S. Raman1, Timothy McClure1, Michael Albert Thomas1
1Radiological Sciences, UCLA, Los Angeles,
Proton magnetic resonance spectroscopic imaging (MRSI) is a promising method for detecting prostate carcinomas showing higher choline and reduced citrate levels in comparison with healthy prostate tissues. 28 prostate cancer patients with different Gleason score is derived from robotic-assisted prostatectomy (GS) underwent endorectal MRSI.There was a significant difference between the (Cho+Cr)/Cit ratio of groups with four different GS (3+3, 3+4, 4+3, 4+4). Low GS shows decreased citrate where as high GS have further decreased or absent citrate and increasing choline. This pilot work demonstrates that changes in relative metabolite levels provided by MRSI can be a non invasive indicator of grade of malignancy.