Jaak Nairismgi1, Ott Rovgeia1, Taavi Pll1, Johanna Nrvinen2, Priit Kogerman1
1Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia, Estonia; 2A.I.Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Egg models are common in experimental science as they are considered as non-animal experiments. However, imaging methods of eggs are technically complicated because of the egg shell and demanding embryo fixation options. Here we implanted mice melanoma (B16F0) tumor cells to the chorioallantoic membrane of 30 chicken eggs and imaged the tumors before hesting by using ultrasonography, magnetic resonance imaging (MRI) and optical imaging methods. Ultrasonography and optical imaging gave information mainly on the size of tumor, but MRI can show also structural changes inside the tumor. In conclusion, we suggest this very cost-effective model for oncobiological applications.