Jeff Snyder1, Richard B. Thompson2, Alan H. Wilman1,2
1Physics, University of Alberta, Edmonton, Alberta, Canada; 2Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
The signal of GABA at 3 ppm in proton spectroscopy is hindered by the large overlapping creatine resonance, requiring alternate methods for detection. This work proposes a PRESS constant echo time difference spectroscopy approach to suppress the creatine signal while maintaining GABA. The technique is simple to implement and only requires changes to timing and flip angle parameters in a standard PRESS sequence. This method is illustrated at 4.7 T.