1GE Global Research Center, Niskayuna, NY, USA
Repeatable and accurate myo-Inositol (mI) detection is important for diagnosing and monitoring multiple pathologic conditions of the brain. The performance of five classes of pulse sequences for mI detection was compared through simulations. These pulse sequences, which included a short TE PRESS, a Carr-Purcell PRESS sequence, an optimized STEAM sequence, an optimized zero quantum filter, and an optimized single quantum filter were compared to a standard PRESS TE=35ms pulse sequence. The simulations results, which were correlated with in vivo experimental data, indicated that the Carr-Purcell sequence offers the most reliable approach for mI measurements at 3T.