Hyla Allouche-Arnon1,2, Ayelet Gamliel3,4, Ruppen Nalbandian3,5, Mor Mishkovsky6, Lucio Frydman6, J. Moshe Gomori3, Robert E. Lenkinski7, Claudia M. Barzilay4, Rachel Katz-Brull3
1Department of Radiology, Hadassah Hebrew
University Medical Center , Jerusalem, Israel; 2Department of
Physiology, The Hebrew University of Jerusalem, Jerusalem, Israel; 3Department
of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel; 4Medicinal
Chemistry- School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem,
Israel; 5Department of Physiology, The Hebrew University of
Jerusalem,, Jerusalem, Israel; 6Department of Chemical Physics,
Weizmann Institute of Science, Rehovot, Israel; 7Department of
Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA, USA
Hyperpolarization,obtained either by PHIP or DNP may result in 10,000 fold
enhancement of the NMR signal. However, its utilization is limited by the decay
of the polarization from the moment of its generation due to T1. Enrichment of
proton positions with Deuterium nuclei is known to prolong the T1 of an adjacent
spin in a manner that is critically dependent on the conformation taken by
the molecule in solution. In this work we report on the deuteration related T1
elongation effect in two neuro-metabolic compounds, namely choline and
dopamine, which may have diagnostic potential for neurodegenerative diseases.