Subhojit Som1, Lee C. Potter, Rizwan Ahmad2, Deepti S. Vikram3, Periannan Kuppusamy2
1Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, USA Minor Outlying Islands; 2Davis Heart and Lung Research Institute, Department of Internal Medicine,, The Ohio State University, Columbus, OH, USA; 3Davis Heart and Lung Research Institute, Department of Internal Medicine,, The Ohio State University, Colmbus, OH, USA
A method is presented to use continuous wave electron paramagnetic resonance (EPR) imaging for rapid measurement of partial pressure of oxygen in three spatial dimensions. A particulate paramagnetic probe is employed to create a sparse distribution of spins in a volume of interest. Reduction of unknown parameters is achieved by using a parametric forward model and exploiting the sparsity of spin distribution. This leads to an order of magnitude reduction in data acquisition time as compared to tradition spectral-spatial imaging. The proposed oximetry method is experimentally demonstrated using an L-band EPR spectrometer.