Audrey H. Selzer1, William D. Rooney1, Thomas M. Barbara1, James A. Goodman1, Charles S. Springer Jr. 1, Xin Li1
1Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA
In vivo intercompartmental water exchange has been studied extensively using labeled water. Here we use proton imaging to monitor the 2HOH concentration change during a bolus injection of deuterated saline solution, and thence measure non-equilibrium transendothelial water transport. This provides a direct comparison of MRI results of water transport with those from other methods.