Robert Karl Kosior1,2, Rachel Sharkey2,3, Paolo Federico2,4, Richard Frayne2,4
1Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada; 2Seaman Family MR Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada; 3Radiology and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; 4Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
A patient may be diagnosed with epilepsy, but without a firm understanding of the seizure focus, or without confidence in the diagnosis. Voxel-based relaxometry (VBR) is a T2 relaxometry technique that may provide information to corroborate, or refute indeterminate information from the other sources. Our objective was to assess the performance of single-subject VBR at 3 T for cases of uncertain epilepsy diagnoses. We found that more VBR abnormalities occur in patients with a suspected focus. Our results show that single subject VBR can help identify seizure foci in patients in whom conventional investigations have failed to yield a diagnosis.