Hellmut Merkle1, Peter van Gelderen1, Shumin Wang1, Bing Yao1, Jeff H. Duyn1
1NINDS, NIH, Bethesda, MD, USA
A novel setup within a 'clinical MRI scanner' is described which is optimized to study brain tissue in vitro with high sensitivity and high resolution (nanoliter size voxels) at 300 MHz. Size, shape and placement of coils (up to 32) within the receive array as well as a B0 correction method is simulated, implemented and experimentally verified. This setup requires little preparation time and is now routinely used to study post mortem brain.