Pallab K. Bhattacharyya1, Robert Bermel2, Micheal Phillips1, Lael Stone2, Mark Lowe1
1Imaging Institute, Cleveland Clinic, Cleveland, OH, USA; 2Neurological Institute, Cleveland Clinic, Cleveland, OH, USA
Recent histopathological data have demonstrated that GABA levels are markedly reduced in MS patients in comparison to healthy controls. We have performed in vivo GABA measurement of sensorimotor cortex for both healthy controls and MS patients at 3 tesla. We found a drop in the cortical GABA level in MS patients. In addition, our preliminary data suggest an inverse correlation between manual task performance and GABA level in MS patients. Our preliminary observation indicates that reduced cortical GABA concentration reflects disease burden.