Janne West1,2, Jan B. Warntjes2,3, Peter Lundberg1,2, Anne Marie Landtblom4
1Department of Medicine and Health, Division of Radiation Physics, Linkping, Sweden; 2Center for Medical Imaging Science and Visualization, Linkping, Sweden; 3Department of Medicine and Health, Division of Clinical Physiology, Linkping, Sweden; 4Department of Clinical and Experimental Medicine, Division of Neurology, Linkping, Sweden
Using quantitative MRI the tissue specific parameters R1, R2 and PD (R1=1/T1, R2=1/T2) are quantified. It is shown that volume fraction of tissues in a voxel can be related to R1, R2 and PD measurements. Using this method it is possible to accurately calculate tissue volumes on a sub-voxel scale. This method were used in a group of patients with Clinically Definite Multiple Sclerosis (CDMS) to asses tissue volumes of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and MS plaque for whole brain coverage.