Minjie Wu1,2, Lei K. Sheu1, Carmen Andreescu1, James T. Becker1, Costin Tanase3, Howard J. Aizenstein1,2
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; 3Magnetic Resonance Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
In this study we have compared performance of 3 templates (Colin27, ICBM152, and an elderly template) in terms of co-localization of fMRI signal in elderly individuals on a finger-tapping task. The maximum t-values, location, and size of the regions were similar for all 3 templates. When we looked specifically at elderly subjects with the most prominent ventricles, we found there was a greater peak and smaller extent for the most medial motor cortex regions, but not in the most lateral motor cortex, which suggests the elderly template may be most beneficial for co-localization in medial structures due to their proximity to the ventricles.