Shashank R. Ramdurg1, Ashish Suri1, Deepak Gupta1, Sujeet Kumar Mewar2, Uma Sharma2, Naranamangalam R. Jagannathan2, Bhavani S. Sharma1
1Department of Neurosurgery, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 2Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India
Cerebral vasospasm causes morbidity and mortality following subarachnoid hemorrhage (SAH). It usually occurs 3 to 9 days after SAH. We evaluated the potential of MRI and MRA to study SAH in a rat model. Direct injection of blood in cisterna magna was used as it provides controlled and quantifiable data to study the pathophysiological changes of SAH. Our study showed that the animal model used provides comparison of diameters of the vascular anatomy of normal rats as well as SAH induced rats. In SAH induced rats, there was partial improvement of the diameters of major vessels on second day.