Mohit Saxena1, Shanmugam Senthil Kumaran2, Sumit Singh1, Vaishna Narang3, Madhuri Behari1
1Neurology, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of NMR, All India Institute of Medical Sciences, New Delhi, Delhi, India; 3School of Languages, Jawaharlal Nehru University, New Delhi, India
Parkinson's disease (PD) is associated with tremor, bradykinesia, rigidity, postural disturbance and speech dysfunction. Using fMRI, we evaluated six PD patients with and without dopa drugs for motor (finger tapping) and speech tasks (Hindi words reading) using block design at 1.5 T. We observed Brodmann area (BA) 6 and middle temporal gyrus after drug administration and reduced activation in sensory motor cortex and middle temporal gyrus. Positive L-dopa effects were observed in right BA 4, 6 for motor tasks and BA 21, 6 for speech tasks in PD subjects. BA 44, 45 and BA 13 showed negative dopaminergic effects.