Guangming Lu1, Zhiqiang Zhang2, Qifu Tan3, Yuan Zhong2, Yijun Liu4
1Medical Imaging, Jinling Hospital, Clinical School of Nanjing University, Nanjing, Jiangsu, China; 2Medical Imaging, Jinling hospital, Clinical School of Nanjing University, Nanjing, Jiangsu, China; 3Neurosurgery, Jinling hospital, Clinical School of Nanjing University, Nanjing, Jiangsu, China; 4Psychiatry, University of Florida, Gainesville, FL, USA
The alternation of the default-mode network (DMN), being as an intrinsic low-frequency fluctuation, is remaining unknown in the medial temporal lobe epilepsy (mTLE). The resting-fMRI data of 44 patients with mTLE were investigated by using the independent component analysis (ICA) and amplitude of low-frequency fluctuation (ALFF) analysis. By comparing with the results of 27 normal controls, ICA and ALFF analysis both revealed that the patients had different changing patterns in the functional connectivity and ALFF within the regions of DMN, which implies that the alternation of DMN may play a mediating role in the process of mTLE.