Malek I. Makki1, Benjamin J. Wilson2, Rajkumar Munian Govindan2, Michael E. Behen3, Harry T. Chugani2
1Radiology, Wayne State University, Detroit, Mi, USA; 2Pediatrics, Wayne State University, Detroit, Mi, USA; 3Psychology, Wayne State University, Detroit, Mi, USA
We used voxel-based-analysis to measure ADC of cortical and subcortical regions within the fronto-striato-thalmo-cortical circuit of 17 right-handed children with Tourette Syndrome and 14 age-matched right-handed controls. Tic severity, hyperactivity, attention, externalizing, internalizing, and obsessive and compulsive problems, were noted. Significant increases of ADC were observed in left and right putamen (p=0.005, p=0.039), orbitofrontal (p=0.017, p=0.007), insular (p=0.008, p=0.021) and left globus pallidus and anterior cingulate (p=0.024, p=0.046). Furthermore, the ADC from right orbitofrontal cortex showed significant positive correlation with the internalizing problem scores (p=0.006).