Rakesh K. Gupta1, Sona Saksena1, Nuzhat Husain2, Mazhar Husain3, Savita Srivastava2, Mahesh Ramola3, Rishi Awasthi1, Kashi N. Prasad4, Ram K.S. Rathore5
1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Pathology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3Neurosurgery, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 4Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 5Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India
DTI data were acquired from eight patients with brain abscess (BA) with an aim to see the difference in the relationship between intercellular cell adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) expression and fractional anisotropy (FA) in the BA wall and cavity and its possible explanation vis--vis histology. Quantitative immunohistochemical analysis was performed for ICAM-1 and LFA-1 in the wall showing maximal positive staining. Higher FA values in the wall compared to the cavity even when ICAM-1 and LFA-1 were not expressed in the collagen fibers suggest that the concentrically laid collagen fibers provide structural orientation and are responsible for increased FA. In the BA, there are different explanations for increased FA in cavity and wall substantiated by histology and immunohistochemistry.